How Turmeric Compounds and Conventional Treatments Work
Type of Drug | How it Works | Risk Factor | Beneficial Turmeric Compound |
---|---|---|---|
ACE Inhibitors (vii.236) (e.g., lisinopril, captopril) (vii.230) WARNING: Can cause persistent cough. (vii.230) |
↓ Production of angiotensin II, a protein that promotes atherosclerosis by: (vii.237-238) ↓ Nitric oxide, a compound that relaxes blood vessels. ↑ Oxidation of LDL cholesterol. ↑ Inflammation. (vii.230) ↓ Progression of atherosclerosis. (vii.230) |
Atherosclerosis: Plaque buildup in arteries that can block blood flow. (vii.224-227) |
Alpha-linolenic acid (vii.18, 239) Alpha-terpineol (vii.20, 48, 209) Curcumin (vii.233) Resveratrol (vii.27, 239) |
Angiotensin Receptor Blockers (vii.237) (e.g., candesartan, valsartan, losartan, and irbesartan) (vii.230) |
↓ Activity of angiotensin II by blocking its entry into blood vessel cells. (vii.230, 237) |
Curcumin (vii.114) Resveratrol (vii.27, 239) |
|
Nitrates (vii.236) (e.g., nitroglycerin) (vii.236) |
↑ Blood flow by relaxing/dilating blood vessels. (vii.236-237) ↑ Blood supply to heart. (vii.230) ↓ Chest pain. (vii.236) |
Alpha-linolenic acid (vii.18, 239) Curcumin (vii.193) |
|
Antiplatelet/Anticoagulant Drugs (vii.236) (e.g., aspirin, heparin, and warfarin) (vii.236) |
↓ Formation of clots. (vii.236) ↓ Blood from clotting. (vii.236) ↓ Clot enlargement. (vii.236) |
Blood clots: Harmful clots that block blood flow in the arteries, heart, and veins. One of the ways antiplatelet drugs work is by reducing levels of compounds in the blood that make it "sticky" (such as fibrinogen). (vii.229, 236) |
Turmerones and Curlone (vii.20, 29, 211) |
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↓ Deposits of collagen and elastin in aorta. (vii.240) ↓ Stiffening of aorta. (vii.240) ↓ Free radicals and oxidative stress. (vii.240) ↓ Blood pressure. (vii.236, 240) |
Curcumin (vii.232) Tetrahydrocurcumin (a natural metabolite of turmeric's curcumin compounds) (vii.240) |
|
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↓ High fibrinogen levels. (vii.229) |
Turmeric Extract (vii.68) |
|
Beta Blockers (vii.236) CAUTION: Can cause erectile dysfunction, depression, and fatigue, and may make asthma, heart failure, and/or diabetes worse. (vii.230) |
↓ Epinephrine activity, a hormone that increases heart rate. (vii.230) ↓ Heart rate. (vii.236) ↓ How hard the heart has to work. (vii.236) ↓ Chest pain. (vii.202) |
Hypertension: Overloads the heart, causes chronic inflammation, and can lead to hypertrophy. (vii.224-227) |
Curcumin (vii.193) |
Calcium Channel Blockers (vii.236) (e.g., amlodipine) (vii.230) NOTE: Less risk of depression and fatigue side effects associated with beta blockers. (vii.230) |
Regulates calcium signaling, which: ↑ Blood flow. (vii.202) ↑ Dilation of blood vessels. (vii.236) ↓ Chest pain. (vii.236) |
||
Diuretics (vii.236) ("water pills") (vii.236) WARNING: May raise blood sugar, lower potassium levels too much, cause leg cramps, and/or cause fatigue. (vii.230) |
↓ Fluid in body. (vii.236) |
||
Digitalis (vii.236) |
Improves heart rhythm. (vii.236) |
Irregular heartbeat (vii.227) |
Alpha-linolenic acid (vii.18, 229) |
Statins (vii.236) (e.g., Crestor™, Lipitor®, Mevacor®, and Zocor®) (vii.230) CAUTION: May cause muscle pain, severe muscle damage, or liver failure (rarely). (vii.230) |
↓ HMG-CoA reductase, enzymes in the liver that make cholesterol. (vii.230) ↓ LDL cholesterol. (vii.230) ↓ Triglycerides. (vii.230) ↑ HDL levels. (vii.230) |
Unhealthy cholesterol levels (vii.227) |
Turmeric Extract (vii.68) 1,8-cineole (vii.29, 71, 137) Alpha-linolenic acid (vii.18, 66) Caffeic acid (vii.20, 48) Curcumin (vii.47, 210, 213, 233) Ferulic acid (vii.22, 47, 214) Resveratrol (vii.22, 27) |
Fibric acid derivatives (vii.230) (e.g., fenofibrate) (vii.230) CAUTION: Increases homocysteine levels. Could increase the risk of serious muscle side effects and/or gallbladder disease in combination with statins. Can increase effects of blood thinners. (vii.230) |
↓ Proteins that transport cholesterol. (vii.230) ↓ Triglycerides. (vii.230) |
Beta-sitosterol (vii.18, 29, 212) Curcumin (vii.210) |
|
Zetia® (vii.230) |
↓ Gene production of a protein involved in cholesterol transport. (vii.242) ↓ Absorption of cholesterol in the intestines. (vii.230) |
Genetics: Family history and genetics are associated with higher risk of heart disease. Also, some people's genes make statins ineffective as a treatment for lowering LDL cholesterol levels. (vii.227, 230) |
Turmeric Essential Oil (vii.243) Curcumin (vii.242) |
Beta Blockers (vii.235) |
↓ Homocysteine levels. (vii.235) |
High homocysteine levels: Having levels higher than 9 μmol/L of this inflammatory marker is associated with increased risk of cardiovascular disease. (vii.229) |
Curcumin (vii.233) |
Synthetic MMP Inhibitors (vii.224) |
↓ Enzymes (stimulated by inflammation) involved in remodeling. (vii.224, 228) |
Enlargement of the heart (cardiac hypertrophy) (vii.224) |
A Multi-Target Herb
Studies show that turmeric compounds could also help combat other risk factors that conventional heart drugs may not. These include: (vii.1, 29, 55, 63, 103, 139, 193, 224-227, 229, 240, 245-246)
- Metabolic syndrome conditions (e.g., diabetes and obesity) associated with increased risk of heart disease progression.
- Toxic substances such as cigarette smoke, radiation, harmful chemicals in the environment, and some chemotherapy drugs can cause damage to the heart and/or increase blood pressure.
- Common viral infections that can be especially harmful in some people, triggering a dangerous immune response, chronic inflammation, enlargement of the heart, and heart failure.
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