Turmeric Regulates Angiogenesis in Metabolic Syndrome
Growth of new blood vessels is a process called angiogenesis. When it works properly, angiogenesis helps with tissue growth and repair. (vii.17)
But angiogenesis promotes disease in an unhealthy environment of chronic inflammation - such as in metabolic syndrome. These conditions include: (vii.2, 17)
- Cancer - Tumors use angiogenesis to grow and spread.
- Obesity - Too much angiogenesis allows fat tissue to grow and accumulate more inflammatory immune system cells.
- Vision loss - Clusters of new blood vessels damage the eyes.
Growth factors are proteins our cells (including fat cells) produce that stimulate angiogenesis. Doctors prescribe drugs that target and reduce abnormally high levels of growth factors to help treat certain kinds of tumors and age-related macular degeneration. (vii.17)
A number of natural plant compounds, including those found in turmeric, inhibit out-of-control growth factors. Some of turmeric's compounds also help regulate leptin levels, a hormone involved in angiogenesis. (vii.17)
| Turmeric Compounds | Effect | |
|---|---|---|
| ↓ VEGF | ↓ IGF-1 | |
| Alpha-linolenic acid (vii.18-19) | ♦ | |
| Caffeic acid (vii.20-21) | ♦ | |
| Curcumin (vii.1, 10, 21-22) | ♦ | ♦ |
| Eugenol (vii.19, 23) | ♦ | |
| Limonene (vii.20, 24) | ♦ | |
| Myricetin (vii.25-26) | ♦ | |
| Quercetin (vii.21, 25) | ♦ | |
| Resveratrol (vii.27-28) | ♦ | ♦ |
| Vitamin C (vii.29-30) | ♦ | |
| Metabolic Syndrome Diseases Involved | ||
| Why Is This Important? | ||
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