Evidence of Turmeric's Skin-Lightening Benefit

Ar-turmerone ^(xi.12, 13)

• Inhibited tyrosinase better than curcumin. ^(xi.79)
• Blocks hormones (such as α-MSH) that stimulate melanin production. ^(xi.79)

Caffeic acid ^(xi.12)

• Inhibits tyrosinase. ^(xi.71)
• Prevents formation of ROS free radicals. ^(xi.71)
• Promotes natural antioxidants. ^(xi.71)

Curcuminoids ^(xi.69)

• Antioxidant compounds that scavenges free radicals better than vitamin E. ^(xi.80)
• Blocks formation of free radicals. ^(xi.80)
• Effectively blocks melanin synthesis better than the natural skin lightener.kojic acid. ^(xi.80)
• Blocks activation of AHR and MITF, transcription factor proteins that increase and regulate melanin production. ^{(xi.64, 65, 71)}
• Inhibits tyrosinase. ^(xi.69)

Ferulic acid ^(xi.22)

• Quenches free radicals. ^(xi.71)
• Inhibits tyrosinase. ^(xi.71)

Linoleic acid ^(xi.18)

• Exfoliates outer layer of discolored skin cells. ^(xi.70)
• Interferes with tyrosinase activity. ^(xi.70)

Myricetin ^(xi.49)

• Blocks activation of AHR, a transcription factor protein that increases melanin production. ^(xi.64, 65)

Quercetin ^(xi.49)

• Blocks activation of AHR, a transcription factor protein that increases melanin production. ^(xi.64, 65)
• Suppresses tyrosinase activity. ^(xi.71)

Resveratrol ^(xi.51-52)

• Blocks expression of MITF, a transcription factor that regulates melanin production. ^(xi.70)
• Blocks activation of AHR, a transcription factor protein that increases melanin production. ^(xi.64, 65)
• Inhibits tyrosinase activity after it's produced. ^(xi.71)

Rho-coumaric acid ^(xi.12)

• Neutralizes free radicals, which prevents activation of tyrosinase. ^(xi.71)

Vanillic acid ^(xi.12)

• Inhibits tyrosinase and the transcription factor and receptor proteins that trigger production of melaninn pigment. ^(xi.71)
• Prevents formation of ROS free radicals. ^(xi.71)

Vitamin C ^(xi13)

• Antioxidant protection. ^(xi.70)

Vitamin E ^(xi.54)

• Antioxidant protection. ^(xi.70)