Can Turmeric Help Treat Diabetic Nephropathy?
The chronic inflammation and high blood pressure found in many people with diabetes can lead to diabetic nephropathy. In fact, diabetes is the most common underlying factor in chronic kidney disease and failure worldwide. (vii.263)
At the cellular level, signs of diabetic nephropathy include: (vii.263)
- ↑ Growth factors and structural proteins (such as collagen) that promote fibrosis and harmful changes in the kidney.
- ↑ Proteins in the urine (a sign of kidney damage and dysfunction).
- ↑ Inflammatory cytokine proteins and immune system cells.
How Can Turmeric Compounds Help?
Multiple animal studies show that turmeric's curcumin compounds exert numerous beneficial effects in animal models of type 2 diabetes. This activity includes benefits in the kidneys: (vii.109, 263)
- ↓ Triglyceride deposits in the kidney.
- ↓ Macrophage immune system cells.
- ↓ Inflammatory transcription factor proteins that trigger production of cytokines.
- ↓ Free radicals.
- ↓ Multiple growth factors.
- ↓ Collagen and fibronectin.
- ↑ Natural antioxidant activity.
Curcumin treatment also lowers elevated levels of proteins in the urine, indicating improved kidney function. (vii.109, 263)
Evidence of Benefit
Results of a clinical study show that turmeric supplements can treat diabetic nephropathy. Reducing the cellular effects of the disease could help prevent or delay diabetic nephropathy from progressing to kidney failure. (vii.277)
| Study Details | Study Results |
|---|---|
Randomized, Double-Blind, Placebo Controlled Clinical Trial40 patients with type 2 diabetic nephropathy were randomly assigned to take a placebo or turmeric supplements. (vii.277) 500 mg of turmeric three times a day for 2 months (or placebo) |
Turmeric supplements significantly: (vii.277)
TGF-β and proteinuria can promote end-stage kidney disease. (vii.277) |
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