Turmeric Compounds Help Suppress White Fat's Dangerous Activity

• High blood sugar and saturated fatty acids activate NF-κB. ^(vii.22)
• Inflammatory cytokine proteins promoted by NF-κB also activate more of it (such as TNF-α). ^(vii.1)

• ↑ Production of inflammatory enzymes and proteins (e.g., COX-2 and TNF-α). ^{(vii.22, 31)}
• ↑ Chronic inflammation found in metabolic syndrome conditions. ^{(vii.22, 31)}

Diabetes drugs, insulin, adiponectin, and some natural compounds all suppress NF-κB. ^{(vii.1, 22)}

Fat cells are prompted to secrete TNF-α under certain conditions, including: ^{(vii.1, 2)}

• Obesity.
• Dietary fat that produces high saturated fat levels in the blood.
• High blood sugar.
• Abnormally high leptin levels in the blood.
• Magnesium deficiency.

• ↑ Chronic inflammation and metabolic disorders, fatty liver disease, and heart disease. ^{(vii.34, 42)}
• ↑ NF-κB. ^(vii.1)
• ↑ Insulin resistance and promotes the development of diabetes. ^(vii.2)
• ↑ Leptin levels in the blood and increases body fat. ^(vii.1)
• ↑ Adhesion molecules. These allow plaque build-up on blood vessel walls. ^(vii.21)
• ↓ Adiponectin. ^(vii.38)

TNF-α also makes pre-adipocytes in fat tissue behave like inflammatory macrophages. ^(vii.43)

Diabetes drugs (such as metformin and rosiglitazone), adiponectin, and natural substances such as alpha-lipoic acid and some turmeric compounds all suppress TNF-α. ^{(vii.1, 41)}