Home Health Cancer Could Turmeric Compounds Help Stop Soft Tissue Sarcomas?

Could Turmeric Compounds Help Stop Soft Tissue Sarcomas?

What Causes Sarcoma?
How Can Turmeric Help?
Clinical Evidence

Most cancers begin in epithelial tissue cells in the body. These are carcinomas. Those that begin in bone, cartilage, fibrous tissues, and muscles represent about 2% of cancers, and are called sarcomas. ^(vi.426)

Studies suggest that turmeric compounds may be able to help treat various sarcomas: ^(vi.240)

Sarcoma Types that Turmeric Compounds May Help
Soft / Connective Tissue Sarcomas	Bone Sarcomas
Chondrosarcoma ^(vi.240) Leiomyosarcoma ^(vi.134) Liposarcoma ^{(vi.134, 427)} Lymphosarcoma ^(vi.102) Reticulum cell sarcoma ^(vi.428) Rhabdomyosarcoma ^(vi.429)	Ewing's sarcoma ^(vi.429) Fibrosarcoma ^(vi.240) Osteosarcoma ^(vi.429)

Research suggests turmeric compounds could help fight sarcoma tumors.

What Causes Sarcoma?

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Environmental factors are linked to many of these sarcomas. These include exposure to toxic chemicals (e.g., dioxin and pesticides) and radiation. Some are also linked to viruses, such as Kaposi's sarcoma, which affects the skin. ^{(vi.318, 430)}

Genetics may also play a role in increasing susceptibility. Li-Fraumeni syndrome is an inherited condition linked to higher risk of cancer at an early age, including soft tissue sarcoma. Rarely, uterine fibroids can transform into uterine leiomyosarcomas. ^{(vi.431, 432)}

How Can Turmeric Help Fight Sarcoma?

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Turmeric and its compounds have anti-inflammatory and antitumor properties that research suggests can help block the growth or spread of various types of sarcomas. Clinical and animal studies indicate that using turmeric or its compounds along with conventional sarcoma therapy can also be beneficial. There are even clinical studies recruiting to study the effects of turmeric's curcumin compounds combined with herbal ashwagandha extract to treat osteosarcoma. ^{(vi.426, 427, 433)}

How Do Turmeric Compounds Work on Sarcomas?

Preclinical lab and animal research show turmeric compounds have the following effects:

Turmeric's Phytochemical and Nutrient Effects in Sarcomas
Turmeric Compound	Effects
Alpha-linolenic acid ^(vi.71) (a polyunsaturated fatty acid)	Question: Can alpha-linolenic acid (ALA) help fight sarcoma? Answer: Preclinical studies show that ALA suppresses osteosarcoma cell growth. ^(vi.434)
Ar-turmerone ^(vi.74)	Question: Can ar-turmerone help fight sarcoma? Answer: Ar-turmerone inhibited sarcoma growth in an animal model. ^(vi.435)
Beta-sitosterol ^(vi.71)	Question: Can beta-sitosterol help fight sarcoma? Answer: Research suggests beta-sitosterol can increase fibrosarcoma cell death. ^(vi.436)
Curcumin and Curcumin Analogs or Metabolites ^{(vi.71, 364)}	Question: Can curcumin help fight sarcoma? Answer: Studies show curcumin and curcumin analogs have a number of effects on prostate cancer, including: Increases apoptosis or cell-cycle arrest in osteosarcoma, Ewing's sarcoma, and rhabdomyosarcoma, including in chemoresistant cancer cells. ^(vi.429) Stimulates autophagy in uterine leiomyosarcoma cells. ^(vi.437) Stimulates endoplasmic reticulum (ER) stress and cell death in liposarcoma cells. ^(vi.427) Boosts proteins that promote apoptosis in sarcoma cancer cells. ^(vi.429) Up-regulates tumor suppressors and receptors that trigger apoptosis in chondrosarcoma cells. ^(vi.438) Triggers transcription factors that stimulate pro-apoptosis enzymes in liposarcoma. ^(vi.427) Promotes enzymes that induce liposarcoma cell death. ^{(vi.134, 427)} Boosts effectiveness of radiation therapy in killing fibrosarcoma cells. ^(vi.240) Improves quality of life in patients with solid tumors undergoing chemotherapy treatment. ^(vi.439) Reduces chondrosarcoma tumor volume by 60%. ^(vi.438) Suppresses growth of leiomyosarcoma tumor cells. ^(vi.134) Inhibits transcription factors and oncogenes that promote osteosarcoma and/or fibrosarcoma tumors. ^{(vi.2, 240, 364, 440)} Down-regulates proteins and enzymes that help sarcoma cancer cells survive, proliferate, and spread. ^{(vi.2, 134, 240, 429, 439, 440)} Blocks enzymes that help fibrosarcoma and chondrosarcoma cells metastasize and spread to other areas of the body. ^{(vi.101, 240)} Suppresses kinase enzymes that promote rhabdomyosarcoma and Ewing's sarcoma growth. ^(vi.2, 429) Inhibits factors that promote angiogenesis and fibrosarcoma growth (synthetic curcumin analogs). ^(vi.240) Reduces inflammatory growth factors in patients with solid tumors. ^(vi.439) Curcumin also increases the effectiveness of resveratrol in blocking sarcoma growth. ^(vi.429)
Curdione ^(vi.74)	Question: Can curdione help fight sarcoma? Answer: Curdione inhibits lymphosarcoma. ^(vi.102)
Eugenol ^(vi.74)	Question: Can curdione help fight sarcoma? Answer: Eugenol promotes apoptosis in osteosarcoma cells. ^(vi.441)
Furanodiene ^(vi.415)	Question: Can furanodiene help fight sarcoma? Answer: Furanodiene suppresses uterine sarcoma tumors. ^(vi.415)
Fisetin ^(vi.79)	Question: Can fisetin help fight sarcoma? Answer: Fisetin boosts the sensitivity of chemoresistant uterine sarcoma cells to doxorubicin chemotherapy. ^(vi.442)
Linoleic acid ^(vi.163) (an omega-6 polyunsaturated fatty acid)	Question: Can linoleic acid help fight sarcoma? Answer: Linoleic acid inhibits osteosarcoma cell growth. ^(vi.434)
Quercetin ^(vi.79)	Question: Can quercetin help fight sarcoma? Answer: Quercetin inhibits the growth of gliosarcoma cells. It also suppresses enzyme activity that stimulates the transformation of healthy cells to sarcoma cancer cells. ^(vi.131)
Resveratrol ^(vi.83)	Question: Can resveratrol help fight sarcoma? Answer: Research shows resveratrol has a number of effects on prostate cancer, including: Promotes tumor suppressors that inhibit sarcoma growth. ^(vi.429) Triggers apoptosis or cell-cycle arrest in osteosarcoma and rhabdomyosarcoma. ^(vi.429) Suppresses transcription factors and adhesion molecules that promote metastasis of fibrosarcoma tumors. ^(vi.364) Resveratrol also increases the effectiveness of curcumin in blocking sarcoma growth. ^(vi.429)
Turmeric Extract	Question: Can turmeric extract help fight sarcoma? Answer: Research shows turmeric extract has a number of effects on prostate cancer, including: Turmeric boosts antioxidant protection during chemotherapy treatment. ^(vi.433) Turmeric reduces damaging side effects to heart from doxorubicin, a standard chemotherapy drug for sarcoma that is highly toxic to the heart. ^{(vi.427, 433)}
Xanthorrhizol ^(vi.123)	Question: Can xanthorrhizol help fight sarcoma? Answer: Xanthorrhizol decreased sarcoma growth in an animal model. ^(vi.435)
Vitamin C ^(vi.71)	Question: Can vitamin C help fight sarcoma? Answer: A case report documented complete, long-term regression of reticulum cell sarcoma with high-dose vitamin C therapy. ^(vi.428)

How Turmeric Compounds Stop Sarcoma Tumors ^{(vi.2, 101, 131, 134, 240, 364, 429, 434-442)}

Clinical Evidence of Turmeric Curcumin Compound Benefit in Sarcoma

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Solid Tumor Clinical Study Results
Study Type	Treatment & Study Length
Double-Blinded, Randomized, Placebo-Controlled Clinical Trial 80 patients with solid tumors. ^(vi.439)	Bioavailability-boosted curcumin supplement, 180 mg/day for 8 weeks in conjunction with standard chemotherapy. ^(vi.439)
Results
The curcumin-treated group of patients experienced significant improvement in quality of life compared to those taking placebo. The turmeric compound also suppressed systemic inflammation. ^(vi.439)

Withania somnifera. ^(vi.303)

Development of new tumor-feeding blood vessels. ^(vi.89)

A difficult-to-treat sarcoma of the connective joint tissue. ^(vi.438)

The most common soft tissue sarcoma. ^(vi.427)

Specifically, Bax. ^(vi.429)

Such as p53, Fas, FasL, and DR-5. ^(vi.438)

Specifically, CHOP. ^(vi.427)

Caspases -3 and -8. ^{(vi.134, 427)}

Such as β-catenin and NF-κB. ^{(vi.2, 240, 364)}

Specifically, c-myc. ^(vi.440)

Specifically, cytokines TNF-α, IL-6, and IL-11, as well as cyclin D1, Bcl-2, survivin, and WNT proteins. ^{(vi.2, 240, 429, 439-440)}

Such as mTOR kinases in leiomyosarcoma tumor cells. ^(vi.134)

MMP-2, -9, and -13 metalloproteases, as well as MT1-MMP and TIMP-2. ^{(vi.101, 240)}

Specifically, mTOR kinases. ^(vi.2, 429)

Specifically, transcription factor AP-1 and VEGF. ^(vi.240)

Transforming growth factor-β (TGF-β). ^(vi.439)

Activation of protein tyrosine kinases (PTKs). ^(vi.131)

Such as p53. ^(vi.429)

Specifically, NF-κB. ^(vi.364)

Such as ICAM-1. ^(vi.364)

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Could Turmeric Compounds Help Stop Soft Tissue Sarcomas?

What Causes Sarcoma?

How Can Turmeric Help Fight Sarcoma?

How Do Turmeric Compounds Work on Sarcomas?

Clinical Evidence of Turmeric Curcumin Compound Benefit in Sarcoma

Healthceuticals® Turmeric Curcumin Complex

100% Certified Organic ingredients

Healthceuticals^® Turmeric Curcumin Complex

100% Certified
Organic ingredients