Dysfunctional Immune System Contributes to Alzheimer's Disease
The immune system has an efficient mechanism called phagocytosis to dispose of waste products in the body. This includes getting rid of Aβ protein fragments that form the clumps and tangled neurons that kill brain cells. Macrophage-type immune system cells are white blood cells. One of their functions is to engulf pathogens and cellular debris and safely dispose of them. (iv.59)
Figure IV.8: Phagocytosis Clears out AΒ Proteins in Brain
But this waste disposal system barely works in Alzheimer's disease patients: (iv.59)
Figure IV.9: Impaired Immune-Phagocytosis System in Alzheimer's Disease
Dysfunctional phagocytosis is due to suppressed gene expression for some key proteins involved in the process. (iv.59)
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