Unregulated Nuclear Factor-Kappa B Is Often a Key Step to Cancer
One of the most important transcription factors involved in cancer development and progression is nuclear factor-kappa B (NF-κB). When a person's healthy, NF-κB is just an inactive protein complex in cells. It's activated by a number of different internal and external stressors, such as: (vi.33, 39)
NF-κB directly and indirectly triggers genes (and the proteins they produce) that control the immune system and cell functions. (vi.33, 39)
Figure VI.3: Activated & Unregulated NF-κB Promotes Cancer
Years of research have established that tightly-controlled NF-κB is critical to how the body responds to stressors in almost every type of cell. However, sometimes NF-κB is not regulated correctly. This can lead to chronic inflammatory conditions, immunity problems, and diseases such as cancer. In fact, NF-κB itself regulates the activity of over 200 genes associated with cancer, including the transformation of normal cells to malignant cancer cells: (vi.10, 39, 121)
Activated NF-κB proteins are found in numerous types of cancers, including: (vi.39)
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