Turmeric compounds may help relieve painful arthritis symptoms.

Evidence that Turmeric Compounds Could Help Relieve Arthritis

Although multiple animal studies indicate that turmeric and its curcumin compounds are likely to help prevent osteoarthritis, rheumatoid arthritis, and possibly even arthritis related to psoriasis, researchers suggest it may not be beneficial in treating the condition. However, clinical studies in human patients with both osteoarthritis and rheumatoid arthritis are more promising. Results indicate that turmeric's curcumin compounds in forms that increase its bioavailability do reduce the symptoms of arthritis.  (v.190-192)

These include:

Clinical Trial
Table V.28: Clinical Evidence of Turmeric Compound Effects in Arthritis
TURMERIC FORM OR COMPOUND TYPE OF STUDY

CURCUMIN

(Nalgesic® Active Ingredient Cumerone 1200®)

OSTEOARTHRITIS

Double blinded, randomized, placebo controlled clinical trial.

STUDY RESULTS
  • In ten patients with osteoarthritis in the thumb, the curcumin formula quickly and significantly reduced pain while increasing grip strength. (v.194)
  • Patients were tested with both single and double doses (1200 and 2400 mg/day). Doubling the dosage did not appear to make that much of a difference, but the researchers note that larger patients may need the higher dosage. (v.194)
 
TURMERIC FORM OR COMPOUND TYPE OF STUDY

CURCUMIN

(Enhanced bioavailability formula BCM-95®)

RHEUMATOID ARTHRITIS

Single blinded, randomized clinical trial comparing curcumin to diclofenac sodium.

STUDY RESULTS

45 patients with mild to moderate RA were randomly assigned to one of three different treatments for 8 weeks: (v.187195)

  • 500 mg twice daily curcumin.
  • 500 mg combined with 50 mg diclofenac sodium twice daily.
  • 50 mg diclofenac sodium twice daily (lower end of a typically prescribed dosage in extended release form).

Results were assessed by the patients and physicians using measurements standardized by the American College of Rheumatology. These include the number of painful and/or swollen joints and ability to perform functions such as dressing, walking, and other daily activities. (v.187)

The study demonstrated that those treated with curcumin by itself showed significantly greater improvement of symptoms than either the other two treatment groups. In addition, the curcumin-treated groups had none of the adverse health issues that were potential negative side effects reported by the drug-only group. (v.187)

 
TURMERIC FORM OR COMPOUND TYPE OF STUDY

CURCUMIN

(1000 mg/day)

OSTEOARTHRITIS OF THE KNEE

3-month randomized clinical trial comparing curcumin’s additive effects to diclofenac treatment.

STUDY RESULTS

88 patients with osteoarthritis of the knee were randomly divided into two groups of 44 patients each and administered one of two treatment regimens: (v.196)

  • 75 mg/day of diclofenac with placebo.
  • 75 mg/day of diclofenac with 1000 mg/day of curcumin.

Although there were no statistically significant differences between the two groups at the end of the study, the group given curcumin reported less pain. The curcumin also tended to improve the patients’ ability to perform daily functions. (v.196)

 
TURMERIC FORM OR COMPOUND TYPE OF STUDY

CURCUMIN COMPOUNDS

(250 mg of curcuminoids in a multiherbal sustained release tablet (NILIN™ SR) containing 272 mg of frankincense and 100 mg of ginger extracts)

OSTEOARTHRITIS OF THE KNEE

Open, industry-funded clinical trial involving 32 adult patients.

STUDY RESULTS
  • Of the 30 patients who completed the 56 day study, all reported significant symptom improvement. (v.197)
  • Patients reported significantly less pain, stiffness, and disability as early as the third day of treatment. (v.197)
  • As measured with a 6 minute distance test, patients could progressively walk greater distances over the course of the study. (v.197)
Standard nonsteroidal anti-inflammatory (NSAID) conventional RA treatment; brand names include Arthrotec®, Cataflam®, Flector®, and Voltaren®. (v.195)
Boswellia serrata.

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